hrp0095fc8.3 | Diabetes and Insulin | ESPE2022

Increased zinc alpha2-glycoprotein in patients with type 1 diabetes

Nourbakhsh Mitra , Nourbakhsh Mona , Golpour Pegah , Momeni Hosein , Razzaghy Azar Maryam

Introduction: Zinc α2-glycoprotein (ZAG) is a single-chain polypeptide with molecular weight of 40-kDa, and is secreted from various tissues. It plays several imperative functions in the human body, such as lipid mobilization and immunoregulation. ZAG enhances lipolysis and is involved in reduction of fatty acids in adipose tissues. ZAG has High sequence similarity to MHC-I molecules and is suggested to be a truncated secretory MHC-I–like protein. ...